Drug interactions
Gabapentin + Hydroxyzine
Severity: Moderate
Gabapentin and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine and gabapentin both cause sedation. Their combination can increase drowsiness, dizziness and impaired cognition, with a risk of respiratory depression in susceptible patients.
What this interaction means in plain words
Gabapentin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective doses and warn about driving and alcohol. Monitor for oversedation and respiratory depression, especially in older patients and those with respiratory disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Gabapentin with Hydroxyzine?
MediHelp rates the interaction as moderate. Gabapentin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine and gabapentin both cause sedation. Their combination can increase drowsiness, dizziness and impaired cognition, with a risk of respiratory depression in susceptible patients.
How serious is the interaction between Gabapentin and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn about driving and alcohol. Monitor for oversedation and respiratory depression, especially in older patients and those with respiratory disease.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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