Drug interactions
Gabapentin + Levomilnacipran
Severity: Minor
Gabapentin and Levomilnacipran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness. Gabapentin is a CNS depressant that can add to the sedative effects of levomilnacipran, and in vulnerable patients this may impair psychomotor performance. Clinically important respiratory depression is uncommon with this pairing but is possible in patients with risk factors.
What this interaction means in plain words
Gabapentin and Levomilnacipran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin belongs to Central Nervous System; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive central nervous system effects (pharmacodynamic); no significant pharmacokinetic interaction is expected.
What to do
Start gabapentin at a low dose and titrate slowly. Monitor for excessive sedation, dizziness and, in patients with respiratory risk factors, for respiratory depression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gabapentin
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Gabapentin with Levomilnacipran?
MediHelp rates the interaction as minor. Gabapentin and Levomilnacipran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness and dizziness. Gabapentin is a CNS depressant that can add to the sedative effects of levomilnacipran, and in vulnerable patients this may impair psychomotor performance. Clinically important respiratory depression is uncommon with this pairing but is possible in patients with risk factors.
How serious is the interaction between Gabapentin and Levomilnacipran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start gabapentin at a low dose and titrate slowly. Monitor for excessive sedation, dizziness and, in patients with respiratory risk factors, for respiratory depression.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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