Drug interactions
Gabapentin + Lurasidone
Severity: Moderate
Gabapentin and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause central nervous system depression, so combined use may increase sedation, dizziness, and impaired psychomotor performance. Serious respiratory depression is a particular concern in older adults, those with lung disease, or with other sedatives.
What this interaction means in plain words
Gabapentin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients about driving and avoiding alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Lurasidone?
MediHelp rates the interaction as moderate. Gabapentin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause central nervous system depression, so combined use may increase sedation, dizziness, and impaired psychomotor performance. Serious respiratory depression is a particular concern in older adults, those with lung disease, or with other sedatives.
How serious is the interaction between Gabapentin and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients about driving and avoiding alcohol.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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