Drug interactions
Gabapentin + Temazepam
Severity: Major
Gabapentin and Temazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine and gabapentin is a CNS depressant. Together they can cause marked sedation and respiratory depression, which may be serious in older patients or those with lung disease.
What this interaction means in plain words
Gabapentin and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gabapentin belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and advise against alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gabapentin
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Gabapentin with Temazepam?
MediHelp rates the interaction as major. Gabapentin and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temazepam is a benzodiazepine and gabapentin is a CNS depressant. Together they can cause marked sedation and respiratory depression, which may be serious in older patients or those with lung disease.
How serious is the interaction between Gabapentin and Temazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and advise against alcohol.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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