Drug interactions
Gabapentin enacarbil + Imipramine
Severity: Moderate
Gabapentin enacarbil and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentinoids combined with other CNS depressants can produce excessive sedation and, in vulnerable patients, respiratory depression. Imipramine adds sedative and anticholinergic effects to this.
What this interaction means in plain words
Gabapentin enacarbil and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression through different pathways.
What to do
Use the lowest effective doses and titrate slowly. Monitor for sedation and respiratory depression, especially in older patients or those with lung disease or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Imipramine?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentinoids combined with other CNS depressants can produce excessive sedation and, in vulnerable patients, respiratory depression. Imipramine adds sedative and anticholinergic effects to this.
How serious is the interaction between Gabapentin enacarbil and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly. Monitor for sedation and respiratory depression, especially in older patients or those with lung disease or renal impairment.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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