Drug interactions
Gabapentin enacarbil + Lorazepam
Severity: Moderate
Gabapentin enacarbil and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is a prodrug of gabapentin and adds to the sedative and respiratory depressant effects of lorazepam. Together they can cause marked drowsiness, impaired psychomotor performance and, particularly in older or compromised patients, clinically significant respiratory depression.
What this interaction means in plain words
Gabapentin enacarbil and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism (GABAergic benzodiazepine effect plus gabapentinoid effect).
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and in patients with lung disease or the elderly. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Lorazepam?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil is a prodrug of gabapentin and adds to the sedative and respiratory depressant effects of lorazepam. Together they can cause marked drowsiness, impaired psychomotor performance and, particularly in older or compromised patients, clinically significant respiratory depression.
How serious is the interaction between Gabapentin enacarbil and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and in patients with lung disease or the elderly. Counsel patients to avoid driving and alcohol.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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