Drug interactions
Gabapentin enacarbil + Nortriptyline
Severity: Moderate
Gabapentin enacarbil and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentinoids and tricyclic antidepressants both depress the CNS, and combined use may increase sedation, dizziness and, rarely, respiratory depression, particularly in older patients or those with respiratory disease.
What this interaction means in plain words
Gabapentin enacarbil and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Start with the lowest doses and titrate slowly, monitoring for sedation and respiratory depression. Take extra care in elderly patients and those with COPD or opioid co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Nortriptyline?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentinoids and tricyclic antidepressants both depress the CNS, and combined use may increase sedation, dizziness and, rarely, respiratory depression, particularly in older patients or those with respiratory disease.
How serious is the interaction between Gabapentin enacarbil and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest doses and titrate slowly, monitoring for sedation and respiratory depression. Take extra care in elderly patients and those with COPD or opioid co-therapy.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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