Drug interactions
Gabapentin enacarbil + Oxazepam
Severity: Major
Gabapentin enacarbil and Oxazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentinoids and benzodiazepines both depress the CNS, and together they raise the risk of marked sedation, dizziness and respiratory depression. The risk is highest in older adults, those with lung disease, and with higher doses.
What this interaction means in plain words
Gabapentin enacarbil and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gabapentin enacarbil belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression through GABAergic potentiation and gabapentinoid α2δ calcium channel modulation.
What to do
Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Take particular care in patients with COPD, renal impairment or other CNS depressants.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Oxazepam?
MediHelp rates the interaction as major. Gabapentin enacarbil and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentinoids and benzodiazepines both depress the CNS, and together they raise the risk of marked sedation, dizziness and respiratory depression. The risk is highest in older adults, those with lung disease, and with higher doses.
How serious is the interaction between Gabapentin enacarbil and Oxazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Take particular care in patients with COPD, renal impairment or other CNS depressants.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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