Drug interactions
Gabapentin enacarbil + Phenelzine
Severity: Moderate
Gabapentin enacarbil and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and gabapentinoids may cause respiratory depression when combined with other CNS depressants. The combination may impair alertness and psychomotor function. Risk is greater in older patients and those with respiratory disease.
What this interaction means in plain words
Gabapentin enacarbil and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective gabapentin enacarbil dose and monitor for sedation and respiratory depression. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Phenelzine?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and gabapentinoids may cause respiratory depression when combined with other CNS depressants. The combination may impair alertness and psychomotor function. Risk is greater in older patients and those with respiratory disease.
How serious is the interaction between Gabapentin enacarbil and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective gabapentin enacarbil dose and monitor for sedation and respiratory depression. Advise patients to avoid driving until the response is known.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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