Drug interactions
Gabapentin enacarbil + Promethazine
Severity: Moderate
Gabapentin enacarbil and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and concomitant use can cause excessive sedation, dizziness and, in vulnerable patients, respiratory depression. Risk is higher in older adults and those with pulmonary disease.
What this interaction means in plain words
Gabapentin enacarbil and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive CNS and respiratory depression from H1 antagonism and gabapentinoid activity.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially in older or respiratory-compromised patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Promethazine?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and concomitant use can cause excessive sedation, dizziness and, in vulnerable patients, respiratory depression. Risk is higher in older adults and those with pulmonary disease.
How serious is the interaction between Gabapentin enacarbil and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially in older or respiratory-compromised patients.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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