Drug interactions
Galantamine + Imatinib
Severity: Minor
Galantamine and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and CYP3A4, both of which metabolize galantamine, so galantamine levels may rise. This could increase cholinergic effects such as nausea, bradycardia and syncope, although the effect is likely modest.
What this interaction means in plain words
Galantamine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6 and CYP3A4 by imatinib reduces galantamine metabolism.
What to do
Monitor heart rate and gastrointestinal tolerance after imatinib is started. Reduce the galantamine dose if cholinergic adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Galantamine with Imatinib?
MediHelp rates the interaction as minor. Galantamine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6 and CYP3A4, both of which metabolize galantamine, so galantamine levels may rise. This could increase cholinergic effects such as nausea, bradycardia and syncope, although the effect is likely modest.
How serious is the interaction between Galantamine and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance after imatinib is started. Reduce the galantamine dose if cholinergic adverse effects occur.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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