Drug interactions
Galantamine + Lapatinib
Severity: Minor
Galantamine and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a CYP3A4 inhibitor and may increase galantamine exposure. This may heighten cholinergic adverse effects, though the expected change is modest.
What this interaction means in plain words
Galantamine and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by lapatinib reduces galantamine clearance.
What to do
Monitor for nausea, vomiting and bradycardia during combined use. Lower the galantamine dose if these effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Galantamine with Lapatinib?
MediHelp rates the interaction as minor. Galantamine and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib is a CYP3A4 inhibitor and may increase galantamine exposure. This may heighten cholinergic adverse effects, though the expected change is modest.
How serious is the interaction between Galantamine and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, vomiting and bradycardia during combined use. Lower the galantamine dose if these effects emerge.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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