Drug interactions
Galantamine + Maprotiline
Severity: Moderate
Galantamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The anticholinergic activity of maprotiline opposes the cholinesterase inhibition of galantamine, so the benefit of the dementia treatment may be reduced. Galantamine can also cause bradycardia, and maprotiline may affect cardiac conduction. Additionally, maprotiline may increase galantamine exposure via CYP2D6 effects.
What this interaction means in plain words
Galantamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between antimuscarinic and cholinesterase inhibitor effects.
What to do
Prefer an antidepressant with minimal anticholinergic activity in patients taking galantamine. If used together, monitor cognitive response and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Maprotiline?
MediHelp rates the interaction as moderate. Galantamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The anticholinergic activity of maprotiline opposes the cholinesterase inhibition of galantamine, so the benefit of the dementia treatment may be reduced. Galantamine can also cause bradycardia, and maprotiline may affect cardiac conduction. Additionally, maprotiline may increase galantamine exposure via CYP2D6 effects.
How serious is the interaction between Galantamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antidepressant with minimal anticholinergic activity in patients taking galantamine. If used together, monitor cognitive response and heart rate.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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