Drug interactions
Galantamine + Propafenone
Severity: Moderate
Galantamine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6, which partly metabolizes galantamine, so galantamine levels may increase. Cholinergic effects such as bradycardia, nausea and vomiting may become more prominent, and bradycardia is relevant with an antiarrhythmic.
What this interaction means in plain words
Galantamine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Propafenone inhibition of CYP2D6 metabolism of galantamine.
What to do
Monitor heart rate and gastrointestinal tolerance, and titrate galantamine slowly. Reduce the galantamine dose if bradycardia or marked adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Propafenone?
MediHelp rates the interaction as moderate. Galantamine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits CYP2D6, which partly metabolizes galantamine, so galantamine levels may increase. Cholinergic effects such as bradycardia, nausea and vomiting may become more prominent, and bradycardia is relevant with an antiarrhythmic.
How serious is the interaction between Galantamine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance, and titrate galantamine slowly. Reduce the galantamine dose if bradycardia or marked adverse effects occur.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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