Drug interactions
Galantamine + Sertraline
Severity: Minor
Galantamine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a weak to moderate CYP2D6 inhibitor and may modestly raise galantamine exposure. This may increase cholinergic effects such as nausea, vomiting, bradycardia and dizziness.
What this interaction means in plain words
Galantamine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated galantamine metabolism by sertraline.
What to do
Monitor heart rate and gastrointestinal tolerance during co-therapy. Slow the galantamine titration if cholinergic effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Sertraline?
MediHelp rates the interaction as minor. Galantamine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is a weak to moderate CYP2D6 inhibitor and may modestly raise galantamine exposure. This may increase cholinergic effects such as nausea, vomiting, bradycardia and dizziness.
How serious is the interaction between Galantamine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance during co-therapy. Slow the galantamine titration if cholinergic effects appear.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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