Drug interactions
Galantamine + Thioridazine
Severity: Moderate
Galantamine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine inhibits CYP2D6, which contributes to galantamine metabolism, so galantamine levels may rise. This may increase cholinergic effects such as nausea, bradycardia and syncope, and the two drugs also have opposing pharmacology.
What this interaction means in plain words
Galantamine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Thioridazine inhibits CYP2D6 and reduces galantamine clearance; anticholinergic effects also oppose galantamine.
What to do
Monitor heart rate and gastrointestinal tolerance and reduce the galantamine dose if cholinergic effects occur. Consider an alternative antipsychotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Thioridazine?
MediHelp rates the interaction as moderate. Galantamine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine inhibits CYP2D6, which contributes to galantamine metabolism, so galantamine levels may rise. This may increase cholinergic effects such as nausea, bradycardia and syncope, and the two drugs also have opposing pharmacology.
How serious is the interaction between Galantamine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance and reduce the galantamine dose if cholinergic effects occur. Consider an alternative antipsychotic.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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