Drug interactions
Galantamine + Zafirlukast
Severity: Minor
Galantamine and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast shows weak CYP3A4 inhibition in vitro, and galantamine is partly metabolized by CYP3A4 and CYP2D6. A clinically relevant increase in galantamine levels is unlikely.
What this interaction means in plain words
Galantamine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak inhibition of CYP3A4 metabolism of galantamine by zafirlukast.
What to do
No adjustment is needed. Watch for cholinergic effects such as nausea, vomiting or bradycardia when starting zafirlukast.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Zafirlukast?
MediHelp rates the interaction as minor. Galantamine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast shows weak CYP3A4 inhibition in vitro, and galantamine is partly metabolized by CYP3A4 and CYP2D6. A clinically relevant increase in galantamine levels is unlikely.
How serious is the interaction between Galantamine and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Watch for cholinergic effects such as nausea, vomiting or bradycardia when starting zafirlukast.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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