Drug interactions
Ganaxolone + Hydrocodone
Severity: Moderate
Ganaxolone and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid with sedating properties, and combining it with an opioid increases the likelihood of somnolence and slowed breathing. The effect is additive and most relevant at initiation or dose increases.
What this interaction means in plain words
Ganaxolone and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from GABA-A positive modulation plus opioid receptor agonism.
What to do
Use the lowest effective doses of each drug and monitor for excessive sedation and respiratory depression. Counsel patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Hydrocodone?
MediHelp rates the interaction as moderate. Ganaxolone and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid with sedating properties, and combining it with an opioid increases the likelihood of somnolence and slowed breathing. The effect is additive and most relevant at initiation or dose increases.
How serious is the interaction between Ganaxolone and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses of each drug and monitor for excessive sedation and respiratory depression. Counsel patients to avoid alcohol and driving until the response is known.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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