Drug interactions
Ganaxolone + Maprotiline
Severity: Moderate
Ganaxolone and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone causes somnolence and maprotiline is also sedating, so together they may produce stronger drowsiness and impaired alertness. Maprotiline can also lower the seizure threshold, opposing the antiseizure aim.
What this interaction means in plain words
Ganaxolone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression; maprotiline also lowers seizure threshold.
What to do
Monitor sedation and seizure frequency and adjust doses if oversedation occurs. Consider a less seizurogenic antidepressant in epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Maprotiline?
MediHelp rates the interaction as moderate. Ganaxolone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone causes somnolence and maprotiline is also sedating, so together they may produce stronger drowsiness and impaired alertness. Maprotiline can also lower the seizure threshold, opposing the antiseizure aim.
How serious is the interaction between Ganaxolone and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure frequency and adjust doses if oversedation occurs. Consider a less seizurogenic antidepressant in epilepsy.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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