Drug interactions
Ganaxolone + Mifepristone
Severity: Minor
Ganaxolone and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, which participates in ganaxolone metabolism, but labeling indicates changes in ganaxolone exposure with CYP3A4 inhibitors are not clinically significant. Any effect is expected to be small.
What this interaction means in plain words
Ganaxolone and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganaxolone belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Possible CYP3A4 inhibition slightly reducing ganaxolone metabolism.
What to do
No dose adjustment is required; observe for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Mifepristone?
MediHelp rates the interaction as minor. Ganaxolone and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4, which participates in ganaxolone metabolism, but labeling indicates changes in ganaxolone exposure with CYP3A4 inhibitors are not clinically significant. Any effect is expected to be small.
How serious is the interaction between Ganaxolone and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; observe for excess sedation.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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