Drug interactions
Ganaxolone + Quetiapine
Severity: Moderate
Ganaxolone and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid with sedative effects, and quetiapine is also sedating. Together they can cause excessive somnolence, dizziness and impaired alertness.
What this interaction means in plain words
Ganaxolone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation by ganaxolone and multi-receptor antagonism by quetiapine.
What to do
Monitor for excess sedation and reduce the dose of one agent if needed. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Quetiapine?
MediHelp rates the interaction as moderate. Ganaxolone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid with sedative effects, and quetiapine is also sedating. Together they can cause excessive somnolence, dizziness and impaired alertness.
How serious is the interaction between Ganaxolone and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the dose of one agent if needed. Advise patients to avoid driving and alcohol.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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