Drug interactions
Ganaxolone + Tranylcypromine
Severity: Moderate
Ganaxolone and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone causes somnolence and sedation, which may add to CNS effects of other psychoactive drugs including tranylcypromine. This can impair alertness and psychomotor performance.
What this interaction means in plain words
Ganaxolone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor for excessive sedation, particularly after starting or adjusting either drug. Reduce ganaxolone dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Tranylcypromine?
MediHelp rates the interaction as moderate. Ganaxolone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone causes somnolence and sedation, which may add to CNS effects of other psychoactive drugs including tranylcypromine. This can impair alertness and psychomotor performance.
How serious is the interaction between Ganaxolone and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, particularly after starting or adjusting either drug. Reduce ganaxolone dose if sedation is troublesome.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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