Drug interactions
Ganciclovir + Hydrochlorothiazide-lisinopril
Severity: Minor
Ganciclovir and Hydrochlorothiazide-lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may reduce renal clearance of ganciclovir by competing for tubular secretion, and volume depletion from diuretics can further reduce its elimination. Higher ganciclovir exposure increases the risk of myelosuppression.
What this interaction means in plain words
Ganciclovir and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganciclovir belongs to Anti Virals; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion and reduced glomerular filtration from volume depletion.
What to do
Dose ganciclovir according to creatinine clearance and monitor blood counts and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as minor. Ganciclovir and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may reduce renal clearance of ganciclovir by competing for tubular secretion, and volume depletion from diuretics can further reduce its elimination. Higher ganciclovir exposure increases the risk of myelosuppression.
How serious is the interaction between Ganciclovir and Hydrochlorothiazide-lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose ganciclovir according to creatinine clearance and monitor blood counts and renal function.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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