Drug interactions
Ganciclovir + Mycophenolate mofetil
Severity: Major
Ganciclovir and Mycophenolate mofetil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cleared by renal tubular secretion, so levels of each may rise, especially in renal impairment. Both can also cause myelosuppression, so additive neutropenia and other cytopenias are a concern.
What this interaction means in plain words
Ganciclovir and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ganciclovir belongs to Anti Virals; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Competition for renal tubular secretion plus additive bone marrow suppression.
What to do
Monitor complete blood counts closely and adjust ganciclovir dose to renal function. Reduce or hold either drug if significant cytopenia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Mycophenolate mofetil?
MediHelp rates the interaction as major. Ganciclovir and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are cleared by renal tubular secretion, so levels of each may rise, especially in renal impairment. Both can also cause myelosuppression, so additive neutropenia and other cytopenias are a concern.
How serious is the interaction between Ganciclovir and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and adjust ganciclovir dose to renal function. Reduce or hold either drug if significant cytopenia develops.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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