Drug interactions
Garlic + Sulindac
Severity: Minor
Garlic and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic supplements may inhibit platelet aggregation and could add to the bleeding tendency caused by NSAIDs. Clinical evidence is limited to case reports and mechanistic data.
What this interaction means in plain words
Garlic and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Garlic belongs to Gastrointestinal Tract; Sulindac belongs to Musculoskeletal.
Why it happens
Garlic constituents such as ajoene may inhibit platelet aggregation, additive to NSAID antiplatelet effect.
What to do
Ask patients about supplement use and advise caution with high-dose garlic products. Monitor for bruising or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Frequently asked questions
Can I take Garlic with Sulindac?
MediHelp rates the interaction as minor. Garlic and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Garlic supplements may inhibit platelet aggregation and could add to the bleeding tendency caused by NSAIDs. Clinical evidence is limited to case reports and mechanistic data.
How serious is the interaction between Garlic and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about supplement use and advise caution with high-dose garlic products. Monitor for bruising or bleeding.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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