Drug interactions
Gefitinib + Lorlatinib
Severity: Moderate
Gefitinib and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gefitinib is metabolized by CYP3A4, and lorlatinib may lower its concentrations and reduce antitumor effect.
What this interaction means in plain words
Gefitinib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing gefitinib metabolism.
What to do
Monitor tumor response. Gefitinib labeling suggests considering a dose increase with strong CYP3A4 inducers, with reduction after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Lorlatinib?
MediHelp rates the interaction as moderate. Gefitinib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gefitinib is metabolized by CYP3A4, and lorlatinib may lower its concentrations and reduce antitumor effect.
How serious is the interaction between Gefitinib and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response. Gefitinib labeling suggests considering a dose increase with strong CYP3A4 inducers, with reduction after the inducer is stopped.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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