Drug interactions
Gemcitabine + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Gemcitabine and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine can reduce the antibody response to inactivated influenza vaccine. Protection may be lower than in healthy people, although the vaccine remains safe and recommended in patients receiving chemotherapy.
What this interaction means in plain words
Gemcitabine and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced myelosuppression and lymphopenia reduce the humoral immune response to vaccination.
What to do
Still vaccinate; where feasible give the vaccine between cycles when counts have recovered. Consider vaccinating close contacts and treating influenza exposure early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Frequently asked questions
Can I take Gemcitabine with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Gemcitabine and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine can reduce the antibody response to inactivated influenza vaccine. Protection may be lower than in healthy people, although the vaccine remains safe and recommended in patients receiving chemotherapy.
How serious is the interaction between Gemcitabine and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Still vaccinate; where feasible give the vaccine between cycles when counts have recovered. Consider vaccinating close contacts and treating influenza exposure early.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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