Drug interactions
Gemcitabine + Meningococcal group b vaccine
Severity: Moderate
Gemcitabine and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine-related immunosuppression may reduce the antibody response to meningococcal group B vaccine, so protection may be inadequate.
What this interaction means in plain words
Gemcitabine and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces the immune response to vaccine antigens.
What to do
Vaccinate before chemotherapy when possible or after immune recovery. Consider revaccination if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Frequently asked questions
Can I take Gemcitabine with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Gemcitabine and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine-related immunosuppression may reduce the antibody response to meningococcal group B vaccine, so protection may be inadequate.
How serious is the interaction between Gemcitabine and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy when possible or after immune recovery. Consider revaccination if given during treatment.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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