Drug interactions
Gemcitabine + Ofatumumab sc
Severity: Moderate
Gemcitabine and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and gemcitabine suppresses bone marrow function, so combined use may increase the risk of infection. The immune effect of ofatumumab can persist long after dosing.
What this interaction means in plain words
Gemcitabine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic myelosuppression.
What to do
Monitor blood counts and for infections, and consider delaying ofatumumab until chemotherapy-related immunosuppression resolves.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Frequently asked questions
Can I take Gemcitabine with Ofatumumab sc?
MediHelp rates the interaction as moderate. Gemcitabine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and gemcitabine suppresses bone marrow function, so combined use may increase the risk of infection. The immune effect of ofatumumab can persist long after dosing.
How serious is the interaction between Gemcitabine and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infections, and consider delaying ofatumumab until chemotherapy-related immunosuppression resolves.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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