Drug interactions
Gemcitabine + Tofacitinib
Severity: Major
Gemcitabine and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine suppresses bone marrow function, and tofacitinib adds further immunosuppression. The combination increases the risk of neutropenia and serious infection.
What this interaction means in plain words
Gemcitabine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemcitabine belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic immunosuppression and bone marrow suppression.
What to do
Avoid concurrent use where feasible and hold tofacitinib during myelosuppressive chemotherapy. Monitor blood counts and infection signs if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Gemcitabine
Frequently asked questions
Can I take Gemcitabine with Tofacitinib?
MediHelp rates the interaction as major. Gemcitabine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemcitabine suppresses bone marrow function, and tofacitinib adds further immunosuppression. The combination increases the risk of neutropenia and serious infection.
How serious is the interaction between Gemcitabine and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where feasible and hold tofacitinib during myelosuppressive chemotherapy. Monitor blood counts and infection signs if combined.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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