Drug interactions
Gemifloxacin + Gemtuzumab
Severity: Moderate
Gemifloxacin and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin prolongs the QT interval, and gemtuzumab ozogamicin carries a labeled warning for QT prolongation. Together they may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances or vomiting and diarrhea common in oncology patients.
What this interaction means in plain words
Gemifloxacin and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check ECG and correct potassium and magnesium before and during combined therapy. Consider a non-QT-prolonging antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Gemtuzumab?
MediHelp rates the interaction as moderate. Gemifloxacin and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin prolongs the QT interval, and gemtuzumab ozogamicin carries a labeled warning for QT prolongation. Together they may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances or vomiting and diarrhea common in oncology patients.
How serious is the interaction between Gemifloxacin and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during combined therapy. Consider a non-QT-prolonging antibiotic if feasible.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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