Drug interactions
Gemifloxacin + Indacaterol inhaled
Severity: Moderate
Gemifloxacin and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin can prolong the QT interval, and beta2 agonists such as indacaterol may cause hypokalemia and QT effects. Combined use may raise the risk of ventricular arrhythmias, mainly at higher doses or with other risk factors.
What this interaction means in plain words
Gemifloxacin and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation.
What to do
Monitor for palpitations and consider ECG and potassium checks in patients with cardiac disease. Use an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Gemifloxacin and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin can prolong the QT interval, and beta2 agonists such as indacaterol may cause hypokalemia and QT effects. Combined use may raise the risk of ventricular arrhythmias, mainly at higher doses or with other risk factors.
How serious is the interaction between Gemifloxacin and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and consider ECG and potassium checks in patients with cardiac disease. Use an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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