Drug interactions
Gemifloxacin + Ketorolac intranasal
Severity: Minor
Gemifloxacin and Ketorolac intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may increase CNS stimulation and the risk of convulsions, although this is mainly described with systemic NSAID use. Systemic exposure from intranasal ketorolac is lower, so the effect is likely small.
What this interaction means in plain words
Gemifloxacin and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAIDs may potentiate fluoroquinolone antagonism at GABA-A receptors, lowering seizure threshold.
What to do
No routine change is needed; counsel patients to report tremor, confusion or seizures, particularly with a seizure history or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Ketorolac intranasal?
MediHelp rates the interaction as minor. Gemifloxacin and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs given with fluoroquinolones may increase CNS stimulation and the risk of convulsions, although this is mainly described with systemic NSAID use. Systemic exposure from intranasal ketorolac is lower, so the effect is likely small.
How serious is the interaction between Gemifloxacin and Ketorolac intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel patients to report tremor, confusion or seizures, particularly with a seizure history or renal impairment.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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