Drug interactions
Gemifloxacin + Ketorolac
Severity: Moderate
Gemifloxacin and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The risk is greatest with predisposing factors such as epilepsy, renal impairment or high doses.
What this interaction means in plain words
Gemifloxacin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Ketorolac belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors may be potentiated by NSAIDs, lowering seizure threshold.
What to do
Avoid the combination in patients with seizure history or other risk factors; otherwise monitor for agitation, tremor or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Ketorolac?
MediHelp rates the interaction as moderate. Gemifloxacin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The risk is greatest with predisposing factors such as epilepsy, renal impairment or high doses.
How serious is the interaction between Gemifloxacin and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history or other risk factors; otherwise monitor for agitation, tremor or seizures.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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