Drug interactions
Gemifloxacin + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Moderate
Gemifloxacin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-rifamycin antibiotics are generally not shown to reduce the efficacy of combined oral contraceptives. The iron component in this product may chelate gemifloxacin if taken together, reducing antibiotic absorption.
What this interaction means in plain words
Gemifloxacin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Iron in the product chelates gemifloxacin in the gut; an effect on contraceptive efficacy via gut flora is unlikely.
What to do
Take gemifloxacin at least 3 hours before or 2 hours after the iron-containing product. Additional contraception is generally not needed unless vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as moderate. Gemifloxacin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-rifamycin antibiotics are generally not shown to reduce the efficacy of combined oral contraceptives. The iron component in this product may chelate gemifloxacin if taken together, reducing antibiotic absorption.
How serious is the interaction between Gemifloxacin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take gemifloxacin at least 3 hours before or 2 hours after the iron-containing product. Additional contraception is generally not needed unless vomiting or severe diarrhea occurs.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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