Drug interactions
Gemifloxacin + Meclofenamate
Severity: Moderate
Gemifloxacin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAID use may increase CNS stimulation and the risk of seizures with fluoroquinolones. The risk is highest in patients with epilepsy, CNS disease, renal impairment, or high antibiotic doses.
What this interaction means in plain words
Gemifloxacin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs may enhance fluoroquinolone inhibition of GABA-A receptor binding, lowering seizure threshold.
What to do
Avoid the combination in patients with a seizure history or other risk factors. Otherwise monitor for neuro-excitatory symptoms and stop the drugs if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Meclofenamate?
MediHelp rates the interaction as moderate. Gemifloxacin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAID use may increase CNS stimulation and the risk of seizures with fluoroquinolones. The risk is highest in patients with epilepsy, CNS disease, renal impairment, or high antibiotic doses.
How serious is the interaction between Gemifloxacin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other risk factors. Otherwise monitor for neuro-excitatory symptoms and stop the drugs if they occur.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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