Drug interactions
Gemifloxacin + Mobocertinib
Severity: Major
Gemifloxacin and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, and mobocertinib carries a boxed warning for QT prolongation and torsades de pointes. Combined use raises the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Gemifloxacin and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization (hERG potassium channel) blockade.
What to do
Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, reduce the mobocertinib dose per labeling, correct potassium and magnesium, and monitor ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Mobocertinib?
MediHelp rates the interaction as major. Gemifloxacin and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, and mobocertinib carries a boxed warning for QT prolongation and torsades de pointes. Combined use raises the risk of serious ventricular arrhythmia.
How serious is the interaction between Gemifloxacin and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, reduce the mobocertinib dose per labeling, correct potassium and magnesium, and monitor ECG closely.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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