Drug interactions
Gemifloxacin + Romidepsin
Severity: Moderate
Gemifloxacin and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is associated with ECG changes including QT prolongation, and gemifloxacin adds to this effect. The combination may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances.
What this interaction means in plain words
Gemifloxacin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and keep potassium and magnesium within normal limits. Prefer a non-QT-prolonging antibiotic if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Romidepsin?
MediHelp rates the interaction as moderate. Gemifloxacin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin is associated with ECG changes including QT prolongation, and gemifloxacin adds to this effect. The combination may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances.
How serious is the interaction between Gemifloxacin and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal limits. Prefer a non-QT-prolonging antibiotic if available.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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