Drug interactions
Gemifloxacin + Typhoid vaccine live
Severity: Major
Gemifloxacin and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine depends on viable Salmonella Typhi to induce protection. Gemifloxacin has activity against Gram-negative enteric bacteria and may reduce the vaccine's effectiveness.
What this interaction means in plain words
Gemifloxacin and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity inhibits the live attenuated vaccine strain, decreasing immunogenicity.
What to do
Administer the live oral vaccine at least 24 hours after the final antibiotic dose, or use the inactivated parenteral vaccine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Typhoid vaccine live?
MediHelp rates the interaction as major. Gemifloxacin and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable Salmonella Typhi to induce protection. Gemifloxacin has activity against Gram-negative enteric bacteria and may reduce the vaccine's effectiveness.
How serious is the interaction between Gemifloxacin and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer the live oral vaccine at least 24 hours after the final antibiotic dose, or use the inactivated parenteral vaccine.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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