Drug interactions
Gemifloxacin + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Gemifloxacin and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta agonist, can affect cardiac repolarization and heart rate, and gemifloxacin prolongs QT. Systemic exposure from the inhaler is low, so the clinical risk is modest but may matter in patients with cardiac risk factors.
What this interaction means in plain words
Gemifloxacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on QT interval and cardiovascular stimulation from beta-agonism, with beta-agonist hypokalemia adding to risk.
What to do
Monitor for palpitations and arrhythmia and check potassium in at-risk patients. Consider an alternative antibiotic in patients with known QT prolongation or heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Gemifloxacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta agonist, can affect cardiac repolarization and heart rate, and gemifloxacin prolongs QT. Systemic exposure from the inhaler is low, so the clinical risk is modest but may matter in patients with cardiac risk factors.
How serious is the interaction between Gemifloxacin and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia and check potassium in at-risk patients. Consider an alternative antibiotic in patients with known QT prolongation or heart disease.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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