Drug interactions
Gemtuzumab + Haloperidol
Severity: Moderate
Gemtuzumab and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT prolongation, and gemtuzumab ozogamicin carries a labeled warning for this effect. Combined use may raise the risk of ventricular arrhythmias, particularly with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Gemtuzumab and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Check ECG and electrolytes at baseline and periodically during treatment, and correct potassium and magnesium abnormalities. Consider an alternative to haloperidol if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Haloperidol?
MediHelp rates the interaction as moderate. Gemtuzumab and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT prolongation, and gemtuzumab ozogamicin carries a labeled warning for this effect. Combined use may raise the risk of ventricular arrhythmias, particularly with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Gemtuzumab and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically during treatment, and correct potassium and magnesium abnormalities. Consider an alternative to haloperidol if the QTc becomes markedly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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