Drug interactions
Gemtuzumab + Hydroxyzine
Severity: Moderate
Gemtuzumab and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and hydroxyzine also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmia, especially in patients with electrolyte disturbances.
What this interaction means in plain words
Gemtuzumab and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check ECG and electrolytes at baseline and during treatment, correcting potassium and magnesium deficits. Consider a non-QT-prolonging alternative to hydroxyzine, such as a non-sedating antihistamine or other antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Gemtuzumab with Hydroxyzine?
MediHelp rates the interaction as moderate. Gemtuzumab and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, and hydroxyzine also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmia, especially in patients with electrolyte disturbances.
How serious is the interaction between Gemtuzumab and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during treatment, correcting potassium and magnesium deficits. Consider a non-QT-prolonging alternative to hydroxyzine, such as a non-sedating antihistamine or other antiemetic.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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