Drug interactions
Gemtuzumab + Itraconazole
Severity: Moderate
Gemtuzumab and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT interval prolongation, so giving them together may add to the arrhythmia risk. Gemtuzumab ozogamicin is also given to patients who often have electrolyte disturbances and other QT-active supportive drugs.
What this interaction means in plain words
Gemtuzumab and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG and check electrolytes before and during treatment, correcting potassium and magnesium. Consider a non-QT-prolonging antifungal if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Itraconazole?
MediHelp rates the interaction as moderate. Gemtuzumab and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT interval prolongation, so giving them together may add to the arrhythmia risk. Gemtuzumab ozogamicin is also given to patients who often have electrolyte disturbances and other QT-active supportive drugs.
How serious is the interaction between Gemtuzumab and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes before and during treatment, correcting potassium and magnesium. Consider a non-QT-prolonging antifungal if QTc becomes markedly prolonged.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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