Drug interactions
Gemtuzumab + Moxifloxacin
Severity: Moderate
Gemtuzumab and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin prolongs the QT interval and gemtuzumab ozogamicin carries a labelled warning about QT prolongation. Using them together may increase the risk of serious ventricular arrhythmia, particularly in patients with electrolyte disturbances.
What this interaction means in plain words
Gemtuzumab and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarisation.
What to do
Monitor the ECG and keep potassium and magnesium within normal range during co-treatment. Choose a non-QT-prolonging antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Moxifloxacin?
MediHelp rates the interaction as moderate. Gemtuzumab and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin prolongs the QT interval and gemtuzumab ozogamicin carries a labelled warning about QT prolongation. Using them together may increase the risk of serious ventricular arrhythmia, particularly in patients with electrolyte disturbances.
How serious is the interaction between Gemtuzumab and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and keep potassium and magnesium within normal range during co-treatment. Choose a non-QT-prolonging antibiotic when feasible.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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