Drug interactions
Gemtuzumab + Ribociclib
Severity: Moderate
Gemtuzumab and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib prolongs the QT interval in a concentration-dependent manner, and gemtuzumab ozogamicin has also been associated with QT prolongation. Using both together may raise the risk of torsades de pointes, particularly if electrolyte disturbances are present.
What this interaction means in plain words
Gemtuzumab and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat ECGs and electrolytes during co-treatment. Interrupt or reduce ribociclib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Ribociclib?
MediHelp rates the interaction as moderate. Gemtuzumab and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib prolongs the QT interval in a concentration-dependent manner, and gemtuzumab ozogamicin has also been associated with QT prolongation. Using both together may raise the risk of torsades de pointes, particularly if electrolyte disturbances are present.
How serious is the interaction between Gemtuzumab and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat ECGs and electrolytes during co-treatment. Interrupt or reduce ribociclib if QTc becomes markedly prolonged.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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