Drug interactions
Gemtuzumab + Tacrolimus
Severity: Moderate
Gemtuzumab and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tacrolimus and gemtuzumab ozogamicin have been linked to QT interval prolongation. Used together, particularly in patients with electrolyte disturbances or other QT-prolonging drugs, the risk of arrhythmia may rise.
What this interaction means in plain words
Gemtuzumab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Check ECG and electrolytes before and during treatment, and correct hypokalemia and hypomagnesemia. Review and minimize other QT-prolonging drugs such as azole antifungals, antiemetics or macrolides.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Tacrolimus?
MediHelp rates the interaction as moderate. Gemtuzumab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both tacrolimus and gemtuzumab ozogamicin have been linked to QT interval prolongation. Used together, particularly in patients with electrolyte disturbances or other QT-prolonging drugs, the risk of arrhythmia may rise.
How serious is the interaction between Gemtuzumab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during treatment, and correct hypokalemia and hypomagnesemia. Review and minimize other QT-prolonging drugs such as azole antifungals, antiemetics or macrolides.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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