Drug interactions
Gemtuzumab + Voriconazole
Severity: Moderate
Gemtuzumab and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are associated with QT prolongation, and gemtuzumab ozogamicin labeling advises ECG monitoring with such drugs. The combination may raise the risk of ventricular arrhythmias, especially in patients with electrolyte disturbances.
What this interaction means in plain words
Gemtuzumab and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and electrolytes, correct hypokalemia and hypomagnesemia, and avoid additional QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Voriconazole?
MediHelp rates the interaction as moderate. Gemtuzumab and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are associated with QT prolongation, and gemtuzumab ozogamicin labeling advises ECG monitoring with such drugs. The combination may raise the risk of ventricular arrhythmias, especially in patients with electrolyte disturbances.
How serious is the interaction between Gemtuzumab and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correct hypokalemia and hypomagnesemia, and avoid additional QT-prolonging drugs where possible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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