Drug interactions
Gentamicin + Indapamide
Severity: Moderate
Gentamicin and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, can cause hypokalemia, hypomagnesemia and volume depletion, and gentamicin can add renal electrolyte loss and kidney toxicity. The combination may increase arrhythmia and nephrotoxicity risk.
What this interaction means in plain words
Gentamicin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Indapamide belongs to Cardiovascular.
Why it happens
Additive renal electrolyte wasting, with diuretic-induced volume depletion increasing aminoglycoside nephrotoxicity.
What to do
Monitor potassium, magnesium and creatinine, and check gentamicin levels. Replace electrolytes and avoid dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Indapamide
Frequently asked questions
Can I take Gentamicin with Indapamide?
MediHelp rates the interaction as moderate. Gentamicin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide, a thiazide-like diuretic, can cause hypokalemia, hypomagnesemia and volume depletion, and gentamicin can add renal electrolyte loss and kidney toxicity. The combination may increase arrhythmia and nephrotoxicity risk.
How serious is the interaction between Gentamicin and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and creatinine, and check gentamicin levels. Replace electrolytes and avoid dehydration.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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