Drug interactions
Gentamicin + Indinavir
Severity: Moderate
Gentamicin and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A P-glycoprotein interaction between indinavir and gentamicin is theoretical, as gentamicin is cleared mainly by glomerular filtration. Indinavir can itself cause crystalluria, nephrolithiasis and renal impairment, which may reduce gentamicin clearance and add to kidney injury.
What this interaction means in plain words
Gentamicin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir-related renal toxicity may reduce aminoglycoside clearance; P-glycoprotein effects are theoretical.
What to do
Monitor serum creatinine and gentamicin concentrations, and keep the patient well hydrated. Adjust the gentamicin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Indinavir?
MediHelp rates the interaction as moderate. Gentamicin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A P-glycoprotein interaction between indinavir and gentamicin is theoretical, as gentamicin is cleared mainly by glomerular filtration. Indinavir can itself cause crystalluria, nephrolithiasis and renal impairment, which may reduce gentamicin clearance and add to kidney injury.
How serious is the interaction between Gentamicin and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin concentrations, and keep the patient well hydrated. Adjust the gentamicin dose if renal function declines.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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