Drug interactions
Gentamicin + Ketorolac intranasal
Severity: Moderate
Gentamicin and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is an NSAID that reduces renal prostaglandin synthesis and can impair renal function, even by the intranasal route at lower exposure. This may reduce gentamicin clearance and add to nephrotoxicity. NSAIDs can also cause hyperkalemia, opposing gentamicin potassium wasting.
What this interaction means in plain words
Gentamicin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration may raise aminoglycoside levels and nephrotoxicity.
What to do
Monitor renal function and gentamicin concentrations, and limit duration of ketorolac. Avoid in patients with existing renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Gentamicin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is an NSAID that reduces renal prostaglandin synthesis and can impair renal function, even by the intranasal route at lower exposure. This may reduce gentamicin clearance and add to nephrotoxicity. NSAIDs can also cause hyperkalemia, opposing gentamicin potassium wasting.
How serious is the interaction between Gentamicin and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and gentamicin concentrations, and limit duration of ketorolac. Avoid in patients with existing renal impairment or dehydration.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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